Image 1 of 1
Natural Factors BioCoenzymated™ Methylfolate Folate + B12 1000 mcg/50 mcg, 60 Sublingual Tabs
Natural Factors BioCoenzymated™ Methylfolate Folate + B12 1000 mcg/50 mcg
Natural Factors BioCoenzymated™ Methylfolate Folate + B12 is a high-potency B-vitamin formula providing 1,000 mcg of methylfolate and 50 mcg of vitamin B12 in bioactive, coenzyme forms. It is designed to support red blood cell formation, homocysteine metabolism, nervous-system function, and energy metabolism.
BioCoenzymated™ • Methylfolate • 1,000 mcg Folate • 50 mcg B12 • Nervous-System & Energy Support
What it is
A targeted combination of methylfolate and vitamin B12 using bioactive forms designed for efficient utilization by the body.
Provides 1,000 mcg of methylfolate
Provides 50 mcg of vitamin B12
Uses BioCoenzymated™ forms of key B vitamins
Supports normal red blood cell formation
Supports healthy nervous-system function
Helps support homocysteine metabolism
Contributes to normal energy metabolism
Who it’s for
Adults looking for targeted folate and B12 supplementation
Individuals wanting support for nervous-system health
People looking for nutritional support for energy metabolism
Those wanting support for normal red blood cell formation
Individuals interested in methylation and homocysteine metabolism
People who prefer bioactive/coenzyme forms of B vitamins
Those looking for a combination of methylfolate and B12 in one formula
What it does
Supports normal red blood cell formation
Helps support healthy homocysteine metabolism
Supports normal nervous-system function
Contributes to normal energy metabolism
Supports normal folate metabolism
Helps support the formation of DNA and genetic material
Supports normal cell division
Helps maintain normal psychological function
Key Ingredient Roles
Methylfolate (Folate): A bioactive form of folate involved in DNA synthesis, cell division, red blood cell formation, and homocysteine metabolism
Vitamin B12: Supports normal red blood cell formation, nervous-system function, energy metabolism, and DNA synthesis
Methylation Support: Folate and B12 work together in biochemical pathways involved in the metabolism of homocysteine
Nervous-System Support: B12 plays an important role in maintaining normal neurological function
Red Blood Cell Support: Both folate and B12 are important for normal blood-cell formation
Cellular Support: Folate is required for normal DNA synthesis and cell division
Energy Metabolism: Vitamin B12 contributes to normal energy metabolism
What’s unique about it?
The combination of 1,000 mcg of methylfolate with 50 mcg of vitamin B12 provides two complementary B vitamins that work together in important metabolic pathways.
The BioCoenzymated™ approach focuses on providing B vitamins in forms that are closer to the biologically active forms used by the body, making this formula particularly appealing for individuals seeking a more targeted B-vitamin supplement.
Folate and B12 are especially important for homocysteine metabolism, red blood cell production, nervous-system health, and cellular DNA synthesis, making them valuable nutrients to consider together.
Important: This product provides a high-potency dose of folate. Individuals who are pregnant, taking medications, or being treated for a vitamin B12 deficiency should discuss appropriate supplementation with a healthcare professional. High folate intake can also correct the anemia associated with B12 deficiency while allowing neurological damage from B12 deficiency to continue, so adequate B12 status is important.
1,000 mcg Methylfolate + 50 mcg B12 = bioactive B-vitamin support for methylation, blood cells, nerves, energy, and cellular health.
Natural Factors BioCoenzymated™ Methylfolate Folate + B12 1000 mcg/50 mcg
Natural Factors BioCoenzymated™ Methylfolate Folate + B12 is a high-potency B-vitamin formula providing 1,000 mcg of methylfolate and 50 mcg of vitamin B12 in bioactive, coenzyme forms. It is designed to support red blood cell formation, homocysteine metabolism, nervous-system function, and energy metabolism.
BioCoenzymated™ • Methylfolate • 1,000 mcg Folate • 50 mcg B12 • Nervous-System & Energy Support
What it is
A targeted combination of methylfolate and vitamin B12 using bioactive forms designed for efficient utilization by the body.
Provides 1,000 mcg of methylfolate
Provides 50 mcg of vitamin B12
Uses BioCoenzymated™ forms of key B vitamins
Supports normal red blood cell formation
Supports healthy nervous-system function
Helps support homocysteine metabolism
Contributes to normal energy metabolism
Who it’s for
Adults looking for targeted folate and B12 supplementation
Individuals wanting support for nervous-system health
People looking for nutritional support for energy metabolism
Those wanting support for normal red blood cell formation
Individuals interested in methylation and homocysteine metabolism
People who prefer bioactive/coenzyme forms of B vitamins
Those looking for a combination of methylfolate and B12 in one formula
What it does
Supports normal red blood cell formation
Helps support healthy homocysteine metabolism
Supports normal nervous-system function
Contributes to normal energy metabolism
Supports normal folate metabolism
Helps support the formation of DNA and genetic material
Supports normal cell division
Helps maintain normal psychological function
Key Ingredient Roles
Methylfolate (Folate): A bioactive form of folate involved in DNA synthesis, cell division, red blood cell formation, and homocysteine metabolism
Vitamin B12: Supports normal red blood cell formation, nervous-system function, energy metabolism, and DNA synthesis
Methylation Support: Folate and B12 work together in biochemical pathways involved in the metabolism of homocysteine
Nervous-System Support: B12 plays an important role in maintaining normal neurological function
Red Blood Cell Support: Both folate and B12 are important for normal blood-cell formation
Cellular Support: Folate is required for normal DNA synthesis and cell division
Energy Metabolism: Vitamin B12 contributes to normal energy metabolism
What’s unique about it?
The combination of 1,000 mcg of methylfolate with 50 mcg of vitamin B12 provides two complementary B vitamins that work together in important metabolic pathways.
The BioCoenzymated™ approach focuses on providing B vitamins in forms that are closer to the biologically active forms used by the body, making this formula particularly appealing for individuals seeking a more targeted B-vitamin supplement.
Folate and B12 are especially important for homocysteine metabolism, red blood cell production, nervous-system health, and cellular DNA synthesis, making them valuable nutrients to consider together.
Important: This product provides a high-potency dose of folate. Individuals who are pregnant, taking medications, or being treated for a vitamin B12 deficiency should discuss appropriate supplementation with a healthcare professional. High folate intake can also correct the anemia associated with B12 deficiency while allowing neurological damage from B12 deficiency to continue, so adequate B12 status is important.
1,000 mcg Methylfolate + 50 mcg B12 = bioactive B-vitamin support for methylation, blood cells, nerves, energy, and cellular health.

